Observe patients attempting to quit smoking with CHANTIX for the occurrence of such symptoms and instruct them to discontinue CHANTIX and contact a healthcare provider if they experience such adverse events. Neuropsychiatric Adverse Events: Postmarketing reports of serious or clinically significant neuropsychiatric adverse events have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, aggression, hostility, agitation, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide.

Provide patients with appropriate educational materials and counseling to support the quit attempt.

Another attempt at treatment is recommended for those who fail to stop smoking or relapse when factors contributing to the failed attempt have been addressed.

Consider dose reduction for patients who cannot tolerate adverse effects.

For patients with end-stage renal disease undergoing hemodialysis, a maximum of 0.5 mg daily may be given if tolerated.

Severe Renal Impairment (estimated creatinine clearance less than 30 mL/min): Begin with 0.5 mg once daily and titrate to 0.5 mg twice daily.

Continue treatment for an additional 12 weeks, for a total of 24 weeks. Patients should begin CHANTIX dosing and reduce smoking by 50% from baseline within the first four weeks, by an additional 50% in the next four weeks, and continue reducing with the goal of reaching complete abstinence by 12 weeks.

Consider a gradual approach to quitting smoking with CHANTIX for patients who are sure that they are not able or willing to quit abruptly.An additional 12 weeks of treatment is recommended for successful quitters to increase likelihood of long-term abstinence.Continuing Weeks: 1 mg twice daily for a total of 12 weeks.Starting Week: 0.5 mg once daily on days 1–3 and 0.5 mg twice daily on days 4–7.

Alternatively, the patient can begin CHANTIX dosing and then quit smoking between days 8 and 35 of treatment. Begin CHANTIX dosing one week before the date set by the patient to stop smoking.

Quit smoking aids for pregnancy